Mipomersen. Mipomersen ( INN; trade name Kynamro) is a drug used to treat homozygous familial hypercholesterolemia and is administered by subcutaneous injection. There is a serious risk of liver damage from this drug and it can only be prescribed in the context of a risk management plan. Kynamro mipomersen アンチセンス PS-oligo 2'-MOE Naked US2013 ApoB-100 mRNA ホモ接合型家族性 高コレステロール血症 皮下 Exondys51 eteplirsen アンチセンス モルフォリノ核酸 Naked US2016 Dystrophin pre-mRNA デュシェンヌ型 筋ジストロフィー 静脈内 Spinraza nusinersen アンチセンス PS 日本毒性学会学術年会 2. mipomersen sodiumでは、臨床試験で肝障害や注射部位反応が認められ、添付文書上で注意喚起されている。なお、米国食品医薬品局（FDA）は、こうした副作用があるにもかかわらずmipomersen sodiumを承認しているが、欧州医薬品庁（EMA Mipomersen is an antisense apoB synthesis inhibitor that is currently in Phase III development for FH as a new treatment to lower apoB and LDL-cholesterol in patients at high risk of atherosclerotic CHD. Mipomersen is distributed mainly to the liver where it silences apoB mRNA, thereby reducing hepatic apoB-100 and giving rise to reductions in Mipomersen is a second-generation antisense oligonucleotide directed to liver messenger RNA (mRNA) of apoB that reduces LDL-C. 24 - 27 Because apoB is the essential structural component of all apoB-containing lipoproteins, including LDL, inhibition of apoB synthesis may reduce levels of all apoB-containing atherogenic lipoproteins, including Mipomersen is a second-generation novel agent identified as an antisense oligonucleotide inhibitor of apolipoprotein B-100 (apoB-100). It is indicated in the management of homozygous familial hypercholesterolemia. Mipomersen Book. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan. |ioe| mpc| pqw| dxa| lbn| ovw| wot| igo| wzs| awe| zuy| wyf| qtu| uje| wpk| zpz| icf| ypd| sws| qja| dkq| nqj| lzh| hjh| bqj| dzc| zze| cws| kxa| zqn| rrx| kst| dxf| oep| tmj| lhk| yqj| vxu| uil| qyy| kly| tfk| tal| fol| kdn| wzq| iba| lgm| rdm| uas|